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Janet E. Lindsley, Ph.D.
Professor of Biochemistry

B.S. in Chemistry, Davidson College, North Carolina

Ph.D. in Biochemistry, University of Wisconsin-Madison

Office:   801-581-2797

Location: EEJMRB 3730

Campus Map 



Selected Publications

Promotion of a Mastery Orientation to Learning in Medical School: Implementation of the Not Yet Pass Grade. 

Colbert-Getz JM, Lindsley J, Moore KB, Formosa T, Pippitt K.
Acad Med. 2023 Jan 1;98(1):52-56. Epub 2022 Sep 27. PMID: 36576767

Am I even a med-student anymore?" A Mixed-Methods Study of the Impact of the Initial Disruptions Caused by the COVID-19 Pandemic on Medical Student Professional Identity Formation

Luman AA, Bagley M, Colbert-Getz JM, Christensen T, Lindsley JE, Chow CJ.
Med Sci Educ. 2022 Oct 18;32(6):1387-1395. eCollection 2022 Dec. PMID: 36277267 

Assessment for Learning with Ungraded and Graded Assessments. 

Pippitt KA, Moore KB, Lindsley JE, Cariello PF, Smith AG, Formosa T, Moser K, Morton DA, Colbert-Getz JM, Chow CJ.
Med Sci Educ. 2022 Sep 14;32(5):1045-1054 . eCollection 2022 Oct. PMID: 36276764

Medical Student Attitudes toward USMLE Step 1 and Health Systems Science - A Multi-Institutional Survey. 

Carmody JB, Green LM, Kiger PG, Baxter JD, Cassese T, Fancher TL, George P, Griffin EJ, Haywood YC, Henderson D, Hueppchen NA, Karras DJ, Leep Hunderfund AN, Lindsley JE, McGuire PG, Meholli M, Miller CS, Monrad SU, Nelson KL, Olson KA, Pahwa AK, Starr SR, Tunkel AR, Van Eck RN, Youm JH, Ziring DJ, Rajasekaran SK.
Teach Learn Med. 2021 Apr-May;33(2):139-153. Epub 2020 Dec 8. PMID: 33289589

Embracing uncertainty: COVID-19 exploration in real time. 

Crawford A, Blitch A, Lindsley JE, Dickerson TT.
Med Educ. 2020 Nov;54(11):1052-1053. Epub 2020 Sep 20. PMID: 32951251

Learning from failure: how eliminating required attendance sparked the beginning of a medical school transformation. 

Lamb S, Chow C, Lindsley J, Stevenson A, Roussel D, Shaffer K, Samuelson W.
Perspect Med Educ. 2020 Oct;9(5):314-317. PMID: 32804346

Complete PubMed Listing

Educational and Administrative Activities

Since closing my research laboratory in 2003, I have dedicated my efforts to teaching, curriculum design and educational research. Beginning in 2010 I have served as Assistant Dean of Curriculum for the medical school, focusing on the basic science components. I am privileged to teach biochemistry to medical students, graduate students and Physician Assistant students. My passion is teaching metabolism from an intuitive perspective, with a strong emphasis on practical nutrition. While many view metabolism as a tedious task in memorizing pathways, I view it as a central component of physiology that is beautifully logical. As such, one of my current projects involves a collaboration with colleagues at Stanford, UCSF and members of the Association of Biochemistry Educators (ABE) and the National Board of Medical Examiners to introduce a metabolic map on course level exams, as well as national licensing exams. We view a metabolic map for biochemistry as analogous to a periodic table for chemistry; providing each of these tools during learning and assessment promotes the development of problem-solving skills while de-emphasizing pure recall.

Prior Research Program

From 1993 to 2003 my lab studied the mechanism of enzymes that alter chromosome structure. Our initial studies involved mostly steady-state and pre-steady-state kinetic analysis of DNA topoisomerase II (topo II). These studies were aimed at understanding how this enzyme utilizes the energy from ATP to transport one duplex of DNA through a transient break in another. We discovered that this homodimeric enzyme, with two identical ATP binding sites, acts asymmetrically with the two ATP hydrolyzed sequentially at different times during the reaction cycle.

These kinetic studies of topo II led us to two other projects. One of these was a genetic analysis of the involvement of topo II in the development of chromosome translocations. We developed a genetic selection for chromosome translocations using S. cerevisiae as our model organism. This selection system allowed us to analyze the involvement of DNA recombination, replication and repair proteins in chromosome translocations. The second project was a biochemical analysis of the complex of proteins that condense chromosomes. We purified and analyzed the condensin complex from yeast in an attempt to determine how it interacts with DNA and utilizes ATP in a mechanism that results in chromatin condensation.