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Janet E. Lindsley, Ph.D.
Associate Professor of Biochemistry

B.S. in Chemistry, Davidson College, North Carolina

Ph.D. in Biochemistry, University of Wisconsin-Madison

Office:   801-581-2797

Location:  5150 EIHG, Eccles Institute of Human Genetics  Map

 

blueberries

Selected Publications

Medical Biochemistry without rote memorization: multi-institution implementation and student perceptions of a nationally standardized metabolic map for learning and assessment.
Spicer, DB, Thompson, KH, Tong, M, Cowan, TM, Fulton, TB, Lindsley JE (2018).
Medical Science Educator

Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6(th) International Conference of the Association of Biochemistry
Niederhoffer EC, Cline SD, Osheroff N, Simmons JM, Diekman AB, Franklin DS, Abali EE, Bateman RC Jr, Fontes JD, Lindsley JE, Pearson D, Rubenstein PA, Slaughter CA, Bernstein JA, Hyland KM, Park VM, Sobering AK, Weiler TA, Dasgupta S.
Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. Med Sci Educ. 2017
Dec;27(4):855-859.
PubMed PMID: 29291139; PubMed Central PMCID: PMC5744257.

What nutrition-related knowledge, skills and attitudes should medical students develop?
Lindsley, JE, Abali, EE, Bikman, BT, Cline, SD, Fulton, T, Lopez, B, Rosenthal, OD, Uhley, VE, Weintraut, RJ, Williams, DP, Wisco, JJ, Thompson, K (2017)
Medical Science Educator, 27: 579-583

What's in a Transition? An Integrative Perspective on Transitions in Medical Education.
Colbert-Getz JM, Baumann S, Shaffer K, Lamb S, Lindsley JE, Rainey R, Randall
K, Roussel D, Stevenson A, Cianciolo AT, Maines T, O'Brien B, Westerman M.
Teach Learn Med. 2016 Oct-Dec;28(4):347-352.
PubMed PMID: 27700251.

The Two-Stage Examination: A Method to Assess Individual Competence and Collaborative Problem Solving in Medical Students.
Lindsley JE, Morton DA, Pippitt K, Lamb S, Colbert-Getz JM.
Acad Med. 2016 Oct;91(10):1384-1387.
PubMed PMID: 27049544; PubMed Central PMCID: PMC5044811.

Blood Glucose Laboratory: Collective Experiences at Three US Medical Schools.
Sabina R, Uhley V, Main B, Lucia V, Lindsley J, Pippitt K, Morton D, Twining S, Havas N (2014).
Available here
MedEdPORTAL Publications.

Revealing the allosterome: systematic identification of metabolite-protein interactions.
Orsak T, Smith TL, Eckert D, Lindsley JE, Borges CR, Rutter J.
Biochemistry. 2012 Jan 10;51(1):225-32. Epub 2011 Dec 9.
PubMed PMID: 22122470.

Medical Biochemistry in the Era of Competencies: Is it Time for the Krebs Cycle to go?
Fulton TB, Ronner P, Lindsley JE (2012) Medical Science Educator, 22, 29-32.

 

Educational and Administrative Activities

Since closing my research laboratory in 2003, I have dedicated my efforts to teaching, curriculum design and educational research. Beginning in 2010 I have served as Assistant Dean of Curriculum for the medical school, focusing on the basic science components. I am privileged to teach biochemistry to medical students, graduate students and Physician Assistant students. My passion is teaching metabolism from an intuitive perspective, with a strong emphasis on practical nutrition. While many view metabolism as a tedious task in memorizing pathways, I view it as a central component of physiology that is beautifully logical. As such, one of my current projects involves a collaboration with colleagues at Stanford, UCSF and members of the Association of Biochemistry Educators (ABE) and the National Board of Medical Examiners to introduce a metabolic map on course level exams, as well as national licensing exams. We view a metabolic map for biochemistry as analogous to a periodic table for chemistry; providing each of these tools during learning and assessment promotes the development of problem-solving skills while de-emphasizing pure recall.

Prior Research Program

From 1993 to 2003 my lab studied the mechanism of enzymes that alter chromosome structure. Our initial studies involved mostly steady-state and pre-steady-state kinetic analysis of DNA topoisomerase II (topo II). These studies were aimed at understanding how this enzyme utilizes the energy from ATP to transport one duplex of DNA through a transient break in another. We discovered that this homodimeric enzyme, with two identical ATP binding sites, acts asymmetrically with the two ATP hydrolyzed sequentially at different times during the reaction cycle.

These kinetic studies of topo II led us to two other projects. One of these was a genetic analysis of the involvement of topo II in the development of chromosome translocations. We developed a genetic selection for chromosome translocations using S. cerevisiae as our model organism. This selection system allowed us to analyze the involvement of DNA recombination, replication and repair proteins in chromosome translocations. The second project was a biochemical analysis of the complex of proteins that condense chromosomes. We purified and analyzed the condensin complex from yeast in an attempt to determine how it interacts with DNA and utilizes ATP in a mechanism that results in chromatin condensation.